Abstracts
Beginning in 1964, observations of sunlight related phenomena in the skin of approximately 2000 subjects, mainly of European ancestry, were made in Sydney, Austalia (34° S. Lat.). Pigmented lesions were counted and many new relationships were indentified. The theory proposed to explain these relationships was of spontaneous or UVLinduced somatic mutation, with evidence of immune rejection responses to the benign or malignant tumours observed. A theory of initiation of tumour formation by somatic mutation of normal tissue differentiation genes was proposed: cells blocked from final differentiation might in many cases fail to recognize normal homoeostatic growth controls.
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Beginning in 1964, observations of sunlight related phenomena in the skin of approximately 2000 subjects, mainly of European ancestry, were made in Sydney, Austalia (34° S. Lat.). Pigmented lesions were counted and many new relationships were indentified. The theory proposed to explain these relationships was of spontaneous or UVLinduced somatic mutation, with evidence of immune rejection responses to the benign or malignant tumours observed. A theory of initiation of tumour formation by somatic mutation of normal tissue differentiation genes was proposed: cells blocked from final differentiation might in many cases fail to recognize normal homoeostatic growth controls.
Please see full information
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