Introduction:
Diagnosis has been the major aspects of liver-related infection, for providing
early advice to patients. Data about the hepatitis B virus (HBV) DNA level
among the Indian population were limited. Objectives: To the best of HBV
diagnosis, the present study was conducted to determine the virus DNA level and
the frequency of infection among the age group and genders in the Indian
region.
Methods: A
total of 926 suspected subjects, 520 (56.15%) male and 406 (43.84%) female,
from east (n = 370), north (n = 410), south (n = 45) and west (n = 101) of ages
between 6 and 75 years (mean age 39.65 ± 15.20 years) included in this study.
Viral DNAs were isolated from the plasma and performed with the artus® HBV RG
PCR assay for HBV specific target.
Results: HBV
DNA was identified in a total of 636/926 (68.68%) subjects; 367 (70.57%) male
and 269 (66.25%) female. Demographic data evaluation of viral infection among
genders within different regions and age groups indicated no significant
difference (P > 0.05). However, among females, HBV DNA infection rate &
viral load exhibited decreased proportion within the southern regions and age
group of 61-75 years (P < 0.05) compared to the male population.
Conclusions: HBV
DNA infection is highly endemic among the suspected Indian population. To
prevent the spread of HBV infection among Indians, it is encouraged with
diagnosis procedure in the DNA level.
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